unconjugated hyperbilirubinemia treatment

Orlistat treatment of unconjugated hyperbilirubinemia in Crigler-Najjar disease: a randomized controlled trial. Treatment of conjugated hyperbilirubinemia is dependent on the cause; it may include supportive or curative measures.

2007 Dec. 62(6):725-30. Jaundice that occurs with unconjugated hyperbilirubinemia is termed acholuric because the urine is not darkened.
High-intensity light-emitting diode (LED) beds may be a safe rescue therapy for severe unconjugated neonatal hyperbilirubinemia. [] In a study of 200 jaundiced neonates at or over 35 weeks' gestation who were phototherapy candidates, the use of a super LED bed achieved …
(See "Unconjugated hyperbilirubinemia in term and late preterm infants: Epidemiology and clinical manifestations", section on 'Bilirubin-induced neurologic dysfunction (BIND)'.) The clinical manifestations, prevention, and treatment of hyperbilirubinemia in term and … ›

[]Failure to diagnose liver toxicity due to ongoing drug or toxin exposure may lead to liver failure and death. Pediatr Res .

Rescue phototherapy and phototherapy in transport for severe unconjugated hyperbilirubinemia.

Unconjugated hyperbilirubinemia can result from increased production, impaired conjugation, or impaired hepatic uptake of bilirubin, a yellow bile pigment produced from hemoglobin during erythrocyte destruction.

… unconjugated hyperbilirubinemia and identifying at-risk infants for severe hyperbilirubinemia are reviewed here.

[Medline] . Dark urine, however, occurs when there is excretion of an excess of water-soluble, conjugated bilirubin. [1, 2] It can also occur naturally in newborns.

Thus, unconjugated bilirubin is never found in urine even when there is an elevated level of unconjugated bilirubin in circulation.

An overview of the management of neonatal unconjugated hyperbilirubinemia, including prevention and treatment of severe hyperbilirubinemia is reviewed here.

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