It is also considered for the treatment of pancreatic and gastric cancers. Oxaliplatin, sold under the brand name Eloxatin, is a cancer medication used to treat colorectal cancer. Like most chemotherapeutic agents, efficacy of oxaliplatin is limited by the development of cellular resistance. 2006). Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. Often it is used together with fluorouracil and folinic acid (leucovorin) in advanced cancer. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. Like most chemotherapeutic agents, efficacy of oxaliplatin is limited by the development of cellular resistance. This medicine may cause harm to an unborn baby. Use oxaliplatin as ordered by your doctor. If you are 65 or older, use oxaliplatin with care. Oxaliplatin forms reactive In this study, we investigate the molecular mechanisms of action of oxaliplatin to identify means of predicting response to this agent. Oxaliplatin is used to treat bowel cancer, stomach cancer, pancreatic cancer and cancer of the oesophagus.It may sometimes be used to treat other cancers. Based on findings from animal reproduction studies and the mechanism of action, in utero exposure to oxaliplatin may result in fetal harm. ... such as carboplatin, oxaliplatin and nedaplatin, are similar to those produced by the parent drug, though different in their relative rates of formation. Oxaliplatin, a platinum-based chemotherapeutic agent with a 1,2-diaminocyclohexane (DACH) carrier ligand, has shown in vitro and in vivo efficacy against many tumor cell lines, including some that are resistant to cisplatin and carboplatin. 1. Oxaliplatin use in palliative and adjuvant treatment of colon cancer is frequently limited by cumulative neurotoxicity, leading to reduced quality of life and decreased dose. It is effective against various types of cancers, including carcinoma … It is given by injection into a vein. Data from these studies indicate that oxaliplatin is active in both platinum-resistant disease and in tumor types that have previously been unresponsive to platinum treatment. Oxaliplatin-induced laryngospasm - A case report.
Oxaliplatin-induced laryngospasm - A case report. However, a major reason for treatment failure still is the existence of tumor intrinsic or acquired resistance. While there is no direct evidence of oxaliplatin-induced pulmonary toxicity, nor is there a known mechanism, it is believed that oxaliplatin depletes the critical antioxidant GSH.
Moreover, it enhances the effect of cisplatin or carboplatin, which is a striking demonstration of differing mechanisms of action. 12.1 Mechanism of Action. We hypothesized that the transient receptor potential melastatin 8 (TRPM8), a putative cold and menthol receptor, contributes to oxaliplatin cold hypersensitivity. Oxaliplatin undergoes nonenzymatic conversion in physiologic solutions to active derivatives via displacement of the labile oxalate ligand. The exact mechanism of action of oxaliplatin is not known. Women must use birth control while taking oxaliplatin. It is given by injection into a vein. ... Oxaliplatin: Mechanism of action and antineoplastic activity. Oxaliplatin is an antineoplastic active substance belonging to a new class of platinum-based compounds in which the platinum atom is complexed with 1,2-diaminocyclohexane (“DACH”) and an oxalate group. How is this medicine (Oxaliplatin) best taken? Oxaliplatin differs from its parent compounds in its mechanisms of action, cellular response and development of resistance, which are not fully understood. Cisplatin is a chemotherapy medication used to treat a number of cancers. Several transient reactive species are formed, including monoaquo and diaquo DACH platinum, which covalently bind with macromolecules. The bulky DACH is thought to contribute greater cytotoxicity than cisplatin and carboplatin. Oxaliplatin, a diaminocyclohexane-containing platinum, has a spectrum of activity and mechanisms of action and resistance that appear to be different from those of other platinum-containing compounds, notably cisplatin. You could have more side effects. The mechanism of this neurotoxicity is unclear, but may relate to neuronal voltage-gated sodium channels involving calcium chelation by a metabolite of the drug.
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